Forget Antibodies. Use Aptamers!™ Forget Antibodies. Use Aptamers!™

Apta-Index™: Thrombopoietin Receptor (AF12505) (ID# 270)

Back to Search Results

Thrombopoietin Receptor (AF12505) (ID# 270)

Thrombopoietin Receptor (AF12505)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
Peptide Thrombopoietin Receptor Protein 2 nM (reported value) N/A NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. The authors also created a dimerized version of AF12505 (AF13948). This peptide aptamer possessed an IC50 of 0.5 nM and EC50 4000 times that of the monomer.
NH2IleGluGlyProThrLeuArgGlnTrpLeuAlaAlaArgAlaCOO 14 1754.06 g/mole

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Cwirla et al. "Peptide Agonist of the Thrombopoietin Receptor as Potent as the Natural Cytokine." Science, 276(1997): 1696-1699.

Have your aptamer oligo synthesized by one of our AFFILIATES

Aptagen, LLC | 250 North Main Street | Jacobus, PA 17407

Forget Antibodies. Use Aptamers!™ Forget Antibodies. Use Aptamers!™