Aptagen, LLC
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA
Rous Sarcoma Virus
Cells
20 nM (reported value)
Binding buffer: 2.5 mM MgCl2, 100 mM NaCl, 20 mM Tris-HCl (pH 7.4)
37°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Reported Kd reflects the concentration of RNA that neutralizes 85-92 percent of RSV. Provided Kd is 3 ug/mL of RSV protein.
Rous Sarcoma Virus (A) (ID# 168)
5'rGprGprGprAprGpfCpfUpfCprAprGprAprApfUprAprAprApfCprGpfCpfUpfCprAprAprGprGprGpfUprAprGprGprGprApfUpfCprGpfUpfUprApfCpfCpfCpfCprGprApfCprApfUpfUpfUpfUprAprApfUprGprGprGpfCpfCprGprApfUprGpfUpfUpfUpfCprGprApfCprApfUprGprAprGprGpfCpfCpfCprGprGprApfUpfCpfCprGprGpfCp3'
87
28169.78 g/mole
861600 L/(mole·cm)
55.17%
1.16
32.69
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Pan et al. Isolation of virus-neutralizing RNAs from a large pool of random sequences." PNAS, 92(1995): 11509-11513.
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