Aptamer Details

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Apt-11 inhibiting α-Synuclein Seeding-Dependent Aggregation (ID# 9419)

Aptamer Chemistry: DNA

Target: α-syn monomers mixed with α-syn 122 seeds

Antigen/Target Category: Small Organic

Binding Temp: 60.8°C

Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.

Specificity: Specific to C-Terminally Truncated α-Synuclein Fibrils

Sequence ():

Length: 80

Molecular Weight: 12097.8 g/mole

Extinction Coefficient: 339900 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Hmila, Issam and Sudhakaran, Indulekha P. and Ghanem, Simona S. and Vaikath, Nishant N. and Poggiolini, Ilaria and Abdesselem, Houari and El-Agnaf, Omar M. A. Inhibition of α-Synuclein Seeding-Dependent Aggregation by ssDNA Aptamers Specific to C-Terminally Truncated α-Synuclein Fibrils. ACS Chemical Neuroscience. 2022. https://doi.org/10.1021/acschemneuro.2c00362

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