Aptamer Details

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CD38jd4a Aptamer against CD38 in Multiple Myeloma (ID# 9402)

Aptamer Chemistry: DNA

Target: CD38, a transmembrane glycoprotein that is expressed on the surface of plasma cells and a therapeutic target for Multiple Myeloma

Antigen/Target Category: Protein

Affinity (Kd): 5.4 ± 0.6 nM (reported value)

Binding Conditions/Buffer: DPBS (5 mmol/L MgCl2 and 4.5 g/L glucose) alongside 1 mg/mL BSA (bovine serum albumin) and 0.1 mg/mL HS-DNA (Herring sperm DNA).

Binding Temp: 25 °C °C

Refolding Protocol: heat at 95 °C for 5 minutes, cool on ice for 5 minutes, and place at room temperature for 10 minutes.

Specificity: High affinity and specificity towards CD38.

Sequence ():

Length: 60

Molecular Weight: 18639 g/mole

Extinction Coefficient: 559600 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Di Jiang, Ling Wang, Hengyi Lin, Xiaoqiu Wu, Mingxin Zhang, Songxiao Xu, Zhenhao Long, Tao Bing, Selection and characterization of aptamers against CD38 for clinical diagnostics, Chinese Chemical Letters (2025), Doi: https://doi.org/10.1016/j.cclet.2025.111502

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