Aptamer Details

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A23P3 Aptamer against IL-23 (P19 subunit) (ID# 9182)

Aptamer Chemistry: DNA

Target: IL-23 (P19 subunit)

Antigen/Target Category: Protein

Affinity (Kd): 1.37 (reported value) nM (reported value)

Binding Conditions/Buffer: Binding Buffer: 50 mM phosphate, 150 mM NaCl, pH 7.8

Binding Temp: 37°C°C

Refolding Protocol: Heated at 95°C for 5 min, Cooled to room temperature for 30 min before binding studies

Specificity: Binds specifically to IL-23 (P19 subunit) and does not cross-react with the P40 subunit or unrelated proteins

Comments: Selected using protein-SELEX Potential for therapeutic and diagnostic applications Featured Secondary Structure is from IT Oligo Analyzer Tool

Sequence ():

Length: 34

Molecular Weight: 10817 g/mole

Extinction Coefficient: 344400 L/(mole·cm)

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

Rezaee, M. A., Shobeiri, S. S., Moghadam, M., Mashayekhi, K., & Sankian, M. (2024). In vitro identification of single-stranded DNA aptamers targeting human IL-23 using the protein-SELEX strategy. Journal of pharmaceutical and biomedical analysis, 247, 116245. https://doi.org/10.1016/j.jpba.2024.116245

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