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C-Reactive Protein (ID# 454)

Aptamer Chemistry: RNA Target: C-Reactive Protein (CRP) Antigen/Target Category: Protein Affinity (Kd): 125 nM (reported value) Binding Conditions/Buffer: SPR Binding Buffer: HEPES at pH 6.5 with 0.005% Tween 20 Binding Temp: 25°C Refolding Protocol: NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Specificity: Binding is stabilized with the addition of CaCl₂ but the aptamer also produces signal in the absence of CaCl₂ Comments:

Sequence (): 5'rGprCprCprUprGprUprAprAprGprGprUprGprGprUprCprGprGprUprGprUprGprGprCprGprAprGprUprGprUprGprUprUprAprGprGprAprGprAprGprAprUprUprGprCp 3' Length: 44 Molecular Weight: 14346.65 g/mole Extinction Coefficient: 444700 L/(mole·cm) GC Content: 56.82% nmoles/OD₂₆₀: 2.25 μg/OD₂₆₀: 32.26

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Reference:

A Bini, M Mascini, et al. Development of an optical RNA-based aptasensor for C-reactive protein. Anal. Bioanal. Chem. 390(2008): 1077-1088

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Aptamer Details

C-Reactive Protein (ID# 454)

A Bini, M Mascini, et al. Development of an optical RNA-based aptasensor for C-reactive protein. Anal. Bioanal. Chem. 390(2008): 1077-1088

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