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Apta-Index™: Amyloid Peptide BetaA4(1– 40) (B55) (ID# 70)

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Amyloid Peptide BetaA4(1– 40) (B55) (ID# 70)

Amyloid Peptide BetaA4(1– 40) (B55)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
RNA Amyloid Peptide BetaA4(1– 40) Peptide 29 nM (reported value) Binding Buffer (10 mM Tris–HCl (pH 7.5), 150 mM NaCl, 5 mM MgCl2, 1 mM EDTA). Incubated at room temperature. N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. This aptamer is specific to polymeric amyloid.
5'-rGprGprGprAprAprUprUprCprGprAprGprCprUprCprGprGprUprAprCprCprUprUprUprAprCprCprGprUprAprAprGprGprCprCprUprGprUprCprUprUprCprGprUprUprUprGprAprCprAprGprCprGprGprCprUprUprGprUprUprGprAprCprCprCprUprCprAprCprAprCprUprUprUprGprUprAprCprCprUprGprCprUprGprCprCprAprAprCprUprGprCprAprGprGprCprAprUprGprCprAprAprGprCprUprUprGprGp-3'
107 34199.41 g/mole 1012800.00 L/(mole·cm) 54.21% 0.99 33.77

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Ylera, Francisco, et al. "Selection of RNA Aptamers to the Alzheimer's Disease Amyloid Peptide." Biochemical and Biophysical Research Communities, 290 (2002): 1583-1588.

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