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Apta-Index™: Botulinum neurotoxin type A (BoNT A) Aptamer (ID# 600)

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Botulinum neurotoxin type A (BoNT A) Aptamer (ID# 600)

Botulinum neurotoxin type A (BoNT A) Aptamer
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA BoNT A Light Chain (BoNT/A-rLc) Protein 34 nM (reported value) 1X Binding Buffer: 20 mM Hepes, 150 mM NaCl, 2 mM KCl, 2 mM MgCl2, 2mM CaCl2 (pH 7.4) N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
5'-dCpdTpdTpdGpdApdGpdTpdGpdTpdCpdApdTpdGpdGpdApdCpdGpdTpdTpdCpdCpdGpdGpdTpdCpdTpdTpdGpdGpdGpdCpdGpdGpdGpdApdTpdApdTpdTpdTpdGpdTpdTpdTpdGpdTpdTpdTpdTpdCpdTpdGpdCpdCpdTpdApdTpdGpdTpdTp-3'
60 18544.08 g/mole 547900.00 L/(mole·cm) 46.67% 1.83 33.85

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

(1) Bogomolova, A., Aldissi, M. “Real-time and label-free analyte detection in a flow-through mode using immobilized fluorescent aptamer/quantum dots molecular switches.” Biosensors and Bioelecgtronics, 66 (2015): 290-296. (2) Lou, X., et al. “Micromagnetic selection of aptamers in microfluidic channels.” PNAS, 106, 9 (2009): 2989-2994.

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