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Apta-Index™: upanap-12 (ID# 472)

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upanap-12 (ID# 472)

* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA Urokinase-type plasminogen activator Protein N/A nM (reported value) HBS, 2 mM MgCl2, 0.1% BSA, and 0.025% Tween20 N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Authors provided IC50,values for inhibition of interaction between human uPA and uPAR with upanap-12 having the lowest value.
79 25480.22 g/mole 805500.00 L/(mole·cm) 44.30% 1.24 31.63

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Daniel Miotto Dupont, Jeppe Buur Madsen, Roland Karl Hartmann, et al. Serum-stable RNA aptamers to urokinase-type plasminogen activator blocking receptor binding. RNA 2010 16: 2360-2369

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