Aptagen, LLC
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA
Plasminogen Activator Inhibitor-1
Protein
1.23 nM (reported value)
HBS buffer (pH 7.4), 2mM MgCl2, 0.05% Tween 20.
N/A°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
E.Coli active PAI-1 variant
Plasminogen Activator Inhibitor-1 (paionap-40) (ID# 465)
5'rGprGprGprGpfCpfCprApfCpfCprAprApfCprGprApfCprApfUpfUpfUprApfUpfCprGprAprApfUpfUprGprApfUprAprApfCpfCpfUpfUprApfCprGpfCprGprAprGprAprGpfCprGpfUprAprGpfUpfUpfCprGpfUpfUprGprApfUprApfUprAprAprApfUprAprGpfUprGpfCpfCpfCprApfUprGprGprApfUpfCp3'
79
25454.12 g/mole
800200 L/(mole·cm)
45.57%
1.25
31.81
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Madsen, J.B., et al. "RNA Aptamers as Conformational Probes and Regulatory Agents for Plasminogen Activator Inhibitor-1." Biochemistry, 49, (2010), 4103-4115.
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