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Apta-Index™: Mouse Transferrin Receptor (GS24) (ID# 449)

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Mouse Transferrin Receptor (GS24) (ID# 449)

Mouse Transferrin Receptor (GS24)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA Mouse Transferrin Receptor (mTfR) Protein N/A nM (reported value) PBS with 1 mM MgCl2 N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Aptamer was internalized via receptor-mediated endocytosis. The authors successfully delivered a-L-iduronidase to enzyme-deficient mouse fibroblasts, with correction of glycosaminoglycan metabolism.
Aptamer binding is not inhibited by mouse transferrin, which suggests that the aptamer binds to a different site on the protein.
5'-dGpdApdApdTpdTpdCpdCpdGpdCpdGpdTpdGpdTpdGpdCpdApdCpdApdCpdGpdGpdTpdCpdApdCpdApdGpdTpdTpdApdGpdTpdApdTpdCpdGpdCpdTpdApdCpdGpdTpdTpdCpdTpdTpdTpdGpdGpdTpdApdGpdTpdCpdCpdGpdTpdTpdCpdGpdGpdGpdApdTp-3'
64 19730.83 g/mole 603000.00 L/(mole·cm) 51.56% 1.66 32.72

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

E F Neufeld et al. Aptamer-based endocytosis of a lysosomal enzyme. Proc. Natl. Acad. Sci. USA 105(2008): 15908-15913

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