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Apta-Index™: Interferon-γ (2'F-1) (ID# 406)

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Interferon-γ (2'F-1) (ID# 406)

Interferon-γ (2'F-1)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA Interferon-y/IFN-y/IFNG Protein 4.4 nM (reported value) Binding Mixture: PBS (138 mM NaC1, 2.7 mM KCl, 8.1 mM Na2HPO4, and 1.1 mM KH2PO4, pH 7.4) containing 1 mM Mg2+ ions and 0.01% human serum albumin. N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. This is a biphasic binding described by a two-Kd model, 4.4/716 nM.
5'-rGprGprGprAprGprGprApfCprGprApfUprGpfCprGprGprApfCprApfCpfCprGpfUpfUprAprApfUpfCpfUprGprAprGprGpfCpfCpfCpfUprGpfUpfCpfCpfUprApfUpfUpfCpfCpfUpfUpfCprApfCprGpfCpfCpfUpfCprAprGprAp-3'
59 18947.24 g/mole 566400.00 L/(mole·cm) 57.63% 1.77 33.45

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Kubik, Mark F., et al. "Isolation and Characterization of 2‘-Fluoro-, 2‘-Amino-, and 2’-Fluoro-/Amino-Modified RNA Ligands to Human IFN-7 That Inhibit Receptor Binding." Journal of Immunology, 159 (1997): 259-267.

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