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Apta-Index™: a-Synuclein Oligomers (T-SO508) (ID# 362)

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a-Synuclein Oligomers (T-SO508) (ID# 362)

a-Synuclein Oligomers (T-SO508)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA a-synuclein oligomers Protein 68 nM (reported value) TBS-T buffer for ELONA assay: 10 mM Tris-HCl, 150 mM NaCl, 5 mM KCl, pH 7.4 with 0.05% Tween 20. Heated to 95°C for 10 min, then cooled at a rate of 2°C/min to a final temperature of 25°C. CD spectrum suggests that this aptamer forms a G-quadruplex.
5'-dGpdCpdCpdTpdGpdTpdGpdGpdTpdGpdTpdTpdGpdGpdGpdGpdCpdGpdGpdGpdTpdGpdCpdGp-3'
24 7528.90 g/mole 220200.00 L/(mole·cm) 75.00% 4.54 34.19

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

K Tsukakoshi. Selection of DNA aptamers that recognize a-synuclein oligomers using a competitive screening method. Anal Chem. 84(2012): 5542-5547

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