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Apta-Index™: Histone H4 N-terminal tail (4.33) (ID# 355)

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Histone H4 N-terminal tail (4.33) (ID# 355)

Histone H4 N-terminal tail (4.33)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA H4 N-terminal tail Protein 1.3 nM (reported value) Low-salt conditions: 100 mM NaCl, 5 mM MgCl2, and 10 mM HEPES (pH 7.5).
High-salt conditions: 500 mM NaCl, 10 mM MgCl2, and 10 mM HEPES (pH 7.5).
N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. Affinities for H3, H2 A, and H2 B histones are also provided.
5'-dTpdGpdGpdTpdGpdGpdGpdGpdTpdTpdCpdCpdCpdGpdGpdGpdApdGpdGpdGpdCpdGpdGpdCpdTpdApdCpdGpdGpdGpdTpdTpdCpdCpdGpdTpdApdApdTpdCpdApdGpdApdTpdTpdTpdGpdTpdGpdTp-3'
50 15592.13 g/mole 473300.00 L/(mole·cm) 60.00% 2.11 32.94

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Yu et al. "Aptamers can Discriminate Alkaline Proteins with High Specificity." Chem. Biochem. , 12(2011): 2659-2666.

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