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Apta-Index™: 8-OHdG (22) (ID# 302)

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8-OHdG (22) (ID# 302)

8-OHdG (22)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
DNA 8-OHdG Other 0.1 nM (reported value) 50 mM Tris–HCl (pH 7.6), 300 mM NaCl, 30 mM KCl, and 5 mM MgCl2 N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
5'-dTpdApdApdTpdApdCpdGpdApdCpdTpdCpdApdCpdGpdTpdApdTpdApdGpdGpdGpdApdApdTpdTpdCpdGpdTpdCpdGpdApdCpdGpdGpdApdTpdGpdCpdGpdGpdGpdCpdGpdApdTpdCpdGpdGpdCpdGpdGpdGpdGpdGpdGpdTpdGpdCpdGpdTpdGpdCpdGpdCpdTpdCpdTpdGpdTpdGpdCpdCpdApdGpdGpdGpdGpdGpdTpdGpdGpdGpdApdCpdApdGpdApdTpdCpdApdTpdApdTpdGpdGpdGpdGpdGpdTpdGpdCpdTpdCpdApdGpdGpdTpdCpdGpdApdCpdGpdCpdApdTpdGpdCpdGpdCpdCpdGp-3'
121 37780.41 g/mole 1161100.00 L/(mole·cm) 63.64% 0.86 32.54

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Miyachi, Y. (2009). Selection of a dna aptmaer that binds 8-ohdg using gmp-agarose. Bioorganic & Medicinal Chemistry Letters, 19(2009), 3619-3622.

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