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Apta-Index™: Heteroaryl dihydropyrimidine (Aptamer 21) (ID# 201)

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Heteroaryl dihydropyrimidine (Aptamer 21) (ID# 201)

Heteroaryl dihydropyrimidine (Aptamer 21)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
RNA Heteroaryldihydropyrimidine (HAP) Small Organic 50 nM (reported value) Selection buffer: 150 mM NaCl, 5 mM MgCl2, and 50 mM HEPES (pH 7.4) N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding. RNA was refolded prior to selection process.
5'-rGprGprGprUprAprGprGprCprCprAprGprGprCprAprGprCprCprAprAprCprUprAprGprCprGprAprGprAprGprCprUprUprAprAprAprUprCprUprCprUprGprAprGprCprCprCprGprAprGprAprGprGprGprUprUprCprAprGprUprGprCprUprGprCprUprUprAprUprGprUprGprGprAprCprGprGprCprUprUp-3'
79 25553.41 g/mole 774800.00 L/(mole·cm) 56.96% 1.29 32.98

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Lau et al. "Evolution and Protein Packaging of Small-Molecule RNA Aptamers." ACS NANO, 5(2011): 7722-7729.

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