Aptagen, LLC
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-F-RNA
Trypanosoma cruzi-Heparan Parasite Receptor
Cells
40 nM (reported value)
50 uM RNA containing 20 mM glucose.
N/A°C
NA If the oligo is a known aptamer sequence: For binding studies, perform a refolding protocol to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
Trypanosoma cruzi-Heparan Parasite Receptor (HS6) (ID# 169)
5'rApfCpfCprGprAprGpfUpfCpfCprAprGprAprAprGpfCpfUpfUprGpfUprAprGpfUprApfCpfUprApfCpfCprGpfCprAprApfCprGpfUpfUprGprGpfCprGpfUpfUpfCprGprGpfCprGpfUpfUprGprGpfCpfCprGpfCprGpfUpfCprApfUpfCprGpfCpfUprAprGpfCpfCpfUprAprGprApfUprGprGprAprGpfUpfUprGprAprApfUpfUpfCpfUpfCpfCpfCpfUprApfUprAprGpfUprGprAprGpfUpfCprGpfUprApfUpfUprApfCp3'
107
34422.25 g/mole
1047600 L/(mole·cm)
52.34%
0.95
32.86
Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.
Ulrich et al. "In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion." The Journal of Biological Chemistry, 277 (2002): 20756-20762.
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