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Apta-Index™: Human Nonpancreatic Secretory Phospholipase A2 (Aptamer 15) (ID# 131)

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Human Nonpancreatic Secretory Phospholipase A2 (Aptamer 15) (ID# 131)

Human Nonpancreatic Secretory Phospholipase A2 (Aptamer 15)
* The secondary structure may not be accurate because of MFOLD limitations on chemistries other than RNA/DNA.
2'-NH2-RNA Human Nonpancreatic Secretory Phospholipase A2 (hnps-PLA2) Small Organic 1.7 nM (reported value) Tris-buffered saline (25 mM Tris, pH 7.4, 150 mM NaCl) Tris potassium calcium buffer (25 mM Tris, 2.5 mM CaCl2, 100 mM KCl) N/A If the oligo is a known aptamer sequence: For binding studies, perform a refolding program to ensure proper function (i.e. binding to antigen or target). Refer to the aptamer reference source for the appropriate refolding parameters and binding conditions. Note: it is unknown whether aptamer functions properly without refolding.
5'-rGprGprGprAprAprAprAprGprAprGprApnCprGprGpnCpnCprGprGpnCprGpnCpnCprApnUprAprGpnCpnCprGprAprGprApnUpnCpnCprGprAprGprGpnUprGpnUpnUprGpnCpnCprGprAprGprAprAp-3'
51 26999.39 g/mole 513200.00 L/(mole·cm) 62.75% 1.95 52.61

Note: Information on this aptamer oligo was obtained from the literature and hasn't been validated by Aptagen.

Bridonneau, P., et al. "High-Affinity Aptamers Selectively Inhibit Human Nonpancreatic Secretory Phospholipase A2 (hnps-PLA2)." Journal of Medicinal Chemistry, 41(1998): 778-786.

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